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Updated: Jul 19, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Published on: April 4, 2025

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1b -/- 瘤激活G-四倍体诱导的DNA损伤,促进端粒超延长

Taylor Takasugi1, Peili Gu1, Fengshan Liang1

  • 1Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

Nucleic acids research
|August 10, 2023
PubMed
概括

在小鼠肉瘤中,POT1b的丧失会通过激活DNA损伤反应导致端粒过度延长. POT1b 展开G-四重复合体来抑制这种反应,这种功能在人类POT1中被保留并与癌症相关.

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