富可丁通过干扰素调节因子3 (IRF3) 减轻炎症,改善败血症
Jingqian Su1, Biyun Guan1, Kunsen Chen1
1Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou 350117, China.
Journal of agricultural and food chemistry
|August 10, 2023
概括
发现来自棕藻的化合物富可桑丁 (FX) 通过准干扰素调节因子3 (IRF3) 来抑制败血症. 这种天然化合物通过减少炎症和调节免疫细胞,在小鼠败血症模型中提高了生存率.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 海洋天然产品 海洋天然产品
背景情况:
- 败血症是一种危及生命的疾病,过度炎症严重影响患者的生存.
- 棕藻中的胡卜素富可桑丁 (FX) 具有抗炎性质,但其在败血症中的确切作用机制尚不清楚.
- 干扰素调节因子3 (IRF3) 在先天免疫反应和炎症中起着至关重要的作用.
研究的目的:
- 阐明福可桑丁 (FX) 在败血症中发挥抗炎作用的分子机制.
- 调查干扰素调节因子3 (IRF3) 在FX介导性败血症改善中的作用.
- 评估FX在败血症临床前模型中的治疗潜力.
主要方法:
- 在体外实验中评估FX对免疫细胞中IRF3酸化的影响.
- 在基中进行分子对接,以预测FX和IRF3之间的结合相互作用.
- 在实体研究中,使用结孔 (CLP) 毒症小鼠模型,包括野生类型和Irf3淘汰赛小鼠.
主要成果:
- 富可丁 (FX) 抑制了IRF3酸化在体外,这表明有直接作用于天生的免疫调节的机制.
- 在体分析证实了FX和IRF3.3之间有利的结合模式.
- 在体内,FX治疗显著降低了亲炎性细胞因子和活性氧物种,调节了免疫细胞种群,并提高了CLP诱导的败血症小鼠的存活率.
- 在野生类型的小鼠中观察到FX的保护作用,其机制进一步得到了与淘汰赛小鼠有关的研究的支持.
结论:
- 富可丁 (FX) 通过向和抑制干扰素调节因子3 (IRF3) 的激活来缓解败血症.
- 通过调节先天性免疫力和减少炎症反应,FX显示出对败血症治疗的治疗潜力.
- 这些发现为FX的分子机制提供了新的见解,并表明其在改善败血症患者生存率的临床适用性.
相关概念视频
Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
173
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
173
Gene Regulation in Microbial Communities: Quorum Sensing
40
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
40
Inflammation
53.9K
Overview
53.9K
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K


