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使用手持式共聚焦拉曼光谱仪对亚托皮炎和牛皮皮肤进行非侵入性生物化学分析和比较

U S Dinish¹, Yik Weng Yew^2,3, Keertana Vinod Ram¹

¹Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Journal of biophotonics

|August 10, 2023

概括

混焦拉曼光谱检测显示,在受亚托皮炎 (AD) 和牛皮影响的皮肤中,有明显的生化差异. 这些发现可能能够对这些炎症性皮肤病进行客观分类和针对性的局部治疗.

科学领域:

生物医学光学生物医学光学
皮肤病学皮肤病学
生物化学生物化学

背景情况:

亚托皮炎 (AD) 和牛皮是常见的炎症性皮肤疾病,具有不同的临床表现.
对受影响皮肤进行准确的生物化学分析对于诊断和治疗开发至关重要.

研究的目的:

通过使用非侵入性共聚焦拉曼光谱法 (CRS) 调查和区分健康的皮肤生化特征,阿托皮炎 (AD) 和牛皮.
为了确定特定的生物标志物,说明每个皮肤状况.

主要方法:

使用一个便携式,内部手持的共聚焦拉曼系统 (CRS),使用671nm和785nm激发激光.
在指纹和高波数区域从皮肤获得了拉曼光谱数据.
分析了光谱数据,以量化水,陶胺 (子类) 和胆固醇的相对量.

主要成果:

观察到相对含水量的下降趋势:健康 > 牛皮 > AD.
与健康皮肤相比,胺3水平在病变性AD和牛皮中较低.
胺2水平在病变性阿尔茨海默病下降,但相对于健康的皮肤,在病变性牛皮病增加.
在病变性牛皮症中,胆固醇水平明显高于病变性牛皮和健康皮肤相比.

结论:

对于健康的皮肤,阿尔茨海默病和牛皮的皮肤,存在不同的生化特征,可通过CRS检测.
这些生化差异,特别是水,胺和胆固醇的差异,可以帮助客观地分类皮肤状况.
这些发现支持开发基于已识别的生物化学标志物的疾病特异性局部治疗的潜力.

关键词:

亚托邦性皮肤炎的发生.陶化物是一种陶化物.胆固醇胆固醇胆固醇是一种与焦点一致的拉曼光谱学牛皮是一种牛皮.皮肤疾病皮肤疾病水水水的水水的水

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