降低调节的脂肪组织表达色基因与增加的环境温度
Núria Oliveras-Cañellas1,2,3,4, José María Moreno-Navarrete1,2,3,4, Paula M Lorenzo4,5
1Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona 17007, Spain.
The Journal of clinical endocrinology and metabolism
|August 10, 2023
概括
环境温度的上升与脂肪组织中关键基因的表达减少有关,这可能会影响肥胖. 这项研究探讨了气候变化和代谢健康之间的联系,表明温度在肥胖患病率中的作用.
科学领域:
- 环境健康 环境健康
- 代谢生理学 代谢生理学
- 遗传学 是一个遗传学.
背景情况:
- 在全球范围内,肥胖患病率正在增加,气候变化和全球变暖被假定是导致因素.
- 将环境温度与肥胖病理生理学联系在一起的证据仍然有限.
研究的目的:
- 研究环境温度对脂肪组织生理学和代谢特征的影响.
- 探索室外温度与发热/色和脂肪生成基因的表达之间的关系.
主要方法:
- 对1083名西班牙人皮下脂肪组织 (SAT) 基因表达的定量聚合酶链反应 (qPCR) 分析.
- 测量血生化变量和阿迪波内克水平.
- 获取环境温度数据和应用单变量,多变量和人工智能分析.
主要成果:
- 在与色相关的SAT基因表达 (UCP1,PRDM16,CIDEA) 和脂肪生成 (FASN,SLC2A4,PLIN1) 和环境温度 (最低,平均,最高) 之间发现了负相关性.
- 温度升高与UCP1和ADIPOQmRNA的SAT表达率降低以及循环中的阿迪波涅克水平降低相关.
- 这些关联在各种分析中仍然显著,包括肥胖患者,没有2型糖尿病的人和冬季.
结论:
- 环境温度升高与脂肪组织中棕色化和皮蛋白相关基因的表达减少有关.
- 这些发现表明,全球变暖与肥胖流行病之间存在潜在的联系机制,特别是考虑到肥胖患病率的北南梯度.
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