血清 perfluoroalkyl 物质和美国青少年的生长和发育:一个全国代表性的横截面研究
Yi-Fan Wang1,2, Xu-Ran Zhang2, Ying-Xue Zou3
1Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.
European journal of pediatrics
|August 10, 2023
概括
和多醇基物质 (PFAS) 与青少年的体重和BMI下降有关. 这些对体重的影响是性别特异性的,突出显示了PFAS暴露在年轻人的潜在发育影响.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 广泛暴露于per-和多基基物质 (PFAS) 引发了人们对有害健康影响的担忧,特别是在儿童中.
- 现有的关于PFAS和儿童发育的研究主要集中在早期生活,有混合的发现和一些性别差异的证据.
研究的目的:
- 研究青少年血清PFAS水平与生长指标 (体重,身高,BMI) 之间的关联.
- 通过检查PFAS对青少年发育的影响来补充目前的研究成果.
主要方法:
- 利用了2015-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多重线性回归分析来评估血清PFAS水平与12-19岁青少年的人类测量测量之间的关系.
- 经统计模型中的相关共变量调整.
主要成果:
- 血清 perfluorooctane 硫酸 (PFOS) 与青少年女性体重年龄z-score降低有关.
- 血清 perfluorononanoic 酸 (PFNA) 与青少年男性的体重年龄z-score降低有关.
- 血清PFOS也与所有青少年参与者的BMIz分数下降有关.
结论:
- PFAS暴露与青少年的体重和BMI有负面关联.
- 观察到PFAS和青春期体重之间的负面关联是性别特异的.
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