降低三大全麻醉学期刊随机对照试验的统计显著性值
Philo Waters1, Brayden Rucker2, Mitchell Love2
1Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA. pwaters@okstate.edu.
Canadian journal of anaesthesia = Journal canadien d'anesthesie
|August 10, 2023
概括
将P值值降低到0.005将改变麻醉学中三分之一随机对照试验 (RCT) 的统计学意义. 这凸显了需要在临床试验结果中仔细解释P值的必要性.
科学领域:
- 医学统计 医学统计
- 麻醉学研究 麻醉学研究
- 基于证据的医学基于证据的医学.
背景情况:
- 传统的0.05的P值值被广泛用于确定医学研究中的统计学意义.
- 重新评估这一门可能会影响随机对照试验 (RCT) 结果的解释.
研究的目的:
- 评估将P值值从0.05降低到0.005对主要麻醉学期刊上发表的RCT的统计学意义的影响.
- 了解更严格的P值值如何影响研究结果的解释.
主要方法:
- 在PubMed系统搜索2020年发表在三个领先的麻醉学期刊上的RCT.
- 纳入标准规定了具有主要终点和干预效应的P值值的RCT.
- 数据提取和选是以掩盖,重复的方式进行的.
主要成果:
- 91个RCT符合纳入标准,其中药物干预是最常见的.
- 在分析的99个主要终点中,58个 (59%) 最初显著 (P <0.05).
- 应用0.005的P值值将使37 (64%) 的这些显著终点被重新归类为"暗示性",从而改变36%的显著性解释.
结论:
- 较低的P值值 (0.005) 将改变研究麻醉学文献中约三分之一的RCT的显著性解释.
- 在评估临床试验结果时,读者应考虑后期概率,以避免误解.
- 建议在医疗领域进行进一步的研究,以通过防止误解RCT结果来提高护理质量.
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