个性化问题:基于多种维生素和多种矿物质的癌症预防中性别的影响
Julij Šelb1,2, Filip Cvetko3, Leon Deutsch3
1The NU B.V., J.H. Oortweg 21, 2333CH, Leiden, The Netherlands. julij.selb@thenu.com.
GeroScience
|August 10, 2023
概括
多种维生素和多种矿物质的补充剂降低了总体和男性的癌症发病率,但不是女性. 这些发现表明,性别影响这些补充剂在预防癌症方面的有效性.
科学领域:
- 营养科学 营养科学
- 预防医学 预防医学
- 在瘤学瘤学.
背景情况:
- 非传染性疾病,如癌症,是健康衰老的一个主要问题.
- 食补充剂,包括多种维生素和多种矿物质 (MVM) 配方,正在研究它们在预防疾病中的潜在作用.
- 个体特征,如性别,可能会调节MVM补充剂的疗效.
研究的目的:
- 调查性别对多维生素多矿物质 (MVM) 补充剂预防癌症疗效的影响.
- 进行针对癌症发病率减少的MVM补充试验的性别特异性元分析.
主要方法:
- 对来自三个主要临床试验 (COSMOS,SU.VI.MAX,PHS2) 的数据进行了元分析.
- 这项分析共包括28558名男性和20542名女性.
- 固定效应 (FE) 和随机效应 (RE) 模型被用于元分析.
主要成果:
- 补充MVM显著降低了总人口中的癌症发病率 (HR 0.93 [95% CI,0.88-0.99]).
- 性别特定的分析显示,男性有显著的益处 (HR 0.91 [95% CI,0.85-0.97] FE;HR 0.88 [95% CI,0.77-1.01] RE).
- 在女性中没有观察到对癌症发病率的显著影响 (HR 1.00 [95% CI,0.88-1.14]).
结论:
- 性似乎是影响MVM补充剂预防癌症有效性的重要因素.
- 补充MVM证明了预防癌症的效果,主要在男性身上.
- 这些发现对未来的研究方向和公共卫生政策有关补充策略的影响.
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