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HDACi依赖的微环境规范化克服了瘤负担引起的T细胞疲劳

Andrew Nguyen1, Dominique Brown1, Ramya Krishnan1

  • 1Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Canada.

Clinical cancer research : an official journal of the American Association for Cancer Research
|August 10, 2023
PubMed
概括

表观遗传重编程可以逆转瘤负担诱导的T细胞疲劳,增强固体瘤的采用性T细胞疗法 (ACT). 这种方法将耗尽的T细胞转化为效应细胞,改善治疗反应.

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