免疫疗法用于治疗局部性泌尿道癌症
Andrea Necchi1, Bishoy M Faltas2, Susan F Slovin3
1Vita-Salute San Raffaele University; IRCCS San Raffaele Hospital, Milan, Italy.
JAMA oncology
|August 10, 2023
概括
免疫疗法 (IO) 正在彻底改变泌尿生殖系统癌症的治疗方法,并显示出超出高级阶段的好处. 最近的试验突出显示了IO.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 生殖尿道癌症 生殖尿道癌症
背景情况:
- 免疫疗法 (IO) 已经改变了晚期生殖尿道癌症的治疗.
- 新出现的证据表明IO在局部和局部发达的生殖尿道瘤中具有好处.
研究的目的:
- 审查免疫疗法在生殖尿道癌症的影响.
- 突出最近的临床试验及其对局部疾病管理的影响.
主要方法:
- 对包括KEYNOTE-057,Checkmate274和KEYNOTE 564.4在内的关键临床试验的审查.
- 在非肌肉侵入性膀癌,肌肉侵入性尿道癌和癌中分析免疫疗法的疗效.
主要成果:
- 批准用于高风险的BCG不响应的非肌肉侵入性膀癌 (KEYNOTE-057) 的 pembrolizumab 单疗法.
- 辅助剂尼沃卢马布在肌肉侵入性尿路细胞癌 (Checkmate274) 中显示出无疾病生存益处.
- 辅助 pembrolizumab 在高风险局部/局部晚期癌中显示无复发生存益处 (KEYNOTE 564).
结论:
- 免疫疗法是针对具有攻击性表型的局部性泌尿癌的新兴范式.
- 瘤学家和科学家必须适应这些不断变化的治疗策略.
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