免疫检查点阻塞反应的临床基因组决定因素在头部和部状细胞癌中
Cristina Valero1, Mahdi Golkaram2, Joris L Vos1
1Head and Neck Service, Immunogenomic Oncology Platform, Department of Surgery, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York, USA.
The Journal of clinical investigation
|August 10, 2023
概括
新的分子亚型和临床基因组分类器改善了在复发性头癌中免疫检查点阻塞反应的预测,仅仅超越了瘤突变负担.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 复发和/或转移的头部和部状细胞癌 (HNSCC) 的预后不佳.
- 免疫检查点封锁 (ICB) 对大多数患者提供了有限的益处.
- 目前的生物标志物,如瘤突变负担 (TMB),具有适度的预测价值.
研究的目的:
- 确定用于预测R/M HNSCC中的ICB反应的新生物标志物.
- 开发一个比单独的TMB更准确的预测模型.
主要方法:
- 用ICB治疗的133名R/M HNSCC患者的整体外组测序.
- 阶层分类以识别分子亚型.
- 随机森林和递归分区分析用于预测建模.
主要成果:
- 确定了六种分子亚型,具有不同的ICB反应和存活率.
- 一个临床基因组模型准确地预测了无进展生存期 (PFS) 和整体生存期 (OS).
- 这个模型的表现优于基于TMB的预测.
结论:
- 确定了驱动HNSCC差异性ICB反应的免疫基因组特征.
- 开发并验证了用于患者风险分层的临床基因组分类器.
- 这个工具可以帮助R/M HNSCC患者在考虑ICB时做出临床决策.
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