在SARS-CoV-2感染期间肺部巨细胞激活与肺病理和严重的COVID-19相关
Janessa Yj Tan1, Danielle E Anderson2,3, Abhay Ps Rathore4
1Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
严重的COVID-19涉及由巨细胞 (MCs) 驱动的肺炎. 这些免疫细胞,当被激活时,在动物模型和人类患者中都会导致肺损伤,这表明MCs是治疗目标.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 病毒学 病毒学
背景情况:
- 肺炎是严重的冠状病毒疾病2019 (COVID-19) 的特征.
- 严重的COVID-19的潜在病理被认为是免疫介导的.
- 乳腺细胞 (MCs) 是呼吸道中的免疫细胞,可以在对病毒和过敏原的反应中促进炎症.
研究的目的:
- 在SARS-CoV-2感染期间,调查巨细胞 (MCs) 在肺炎和组织损伤中的作用.
- 为了确定巨细胞激活和人类COVID-19严重程度之间的关联.
主要方法:
- 在SARS-CoV-2感染的小鼠和非人类灵长类动物中观察杆细胞脱粒化.
- 使用一只小鼠模型的巨细胞缺乏,以评估MC-依赖的肺病理.
- 在人类COVID-19患者中分析转录变化和检测杆细胞特异性蛋白酶 (例如,基酶).
主要成果:
- 在感染的动物模型中,在急性和未解决的呼吸道炎症期间观察到广泛的乳腺细胞脱粒化.
- 缺少母细胞的小鼠表现出间歇性肺炎,出血和的增加.
- 在人类中,需要补充氧气的患者的转录形状表明杆细胞表型,高化学酶水平与疾病严重程度和血管失调相关.
结论:
- 巨细胞激活与动物模型中SARS-CoV-2感染期间的肺组织损伤有关.
- 巨细胞激活与人类的严重COVID-19有关,特别是在血管调节失调方面.
- 向巨细胞可能代表严重COVID-19的潜在治疗策略.
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