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Updated: Jul 19, 2025

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人类细胞巨乳病毒向ADAM17,重塑细胞表面蛋白质组,同时调节多个免疫通路

Anzelika Rubina1, Mihil Patel1, Katie Nightingale2

  • 1Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|August 10, 2023
PubMed
概括

人类细胞巨乳病毒 (HCMV) 通过向蛋白酶ADAM17,稳定114种蛋白质来破坏免疫力. 这种病毒机制广泛调节免疫反应和NK细胞抑制.

关键词:
亚当17年 亚当17年人类细胞巨型病毒病毒.免疫调节 免疫调节

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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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