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优化多草药配方的总含量,总黄含量和抗痛风性能

Lim Sin Yee¹, Mohd Fadzelly Abu Bakar¹, Norazlin Abdullah¹

¹Department of Technology and Natural Resources, Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia, UTHM Pagoh Campus, Muar, Johor, Malaysia.

Journal of complementary & integrative medicine

|August 10, 2023

概括

这项研究优化了使用富含和黄化合物的药用植物治疗痛风的方法. 最好的配方结合了Orthosiphon stamineus和Stevia rebaudiana,以获得最大的抗痛风活性.

科学领域:

植物化学植物化学
药理学药理学是指药理学的学科.
传统医学的传统医学.

背景情况:

痛风的患病率正在增加,推动了对自然治疗的研究.
含有和黄的药用植物为传统的痛风药物提供了潜在的替代品.
对抗痛风性质的多草药配方的优化尚未得到充分研究.

研究的目的:

确定Strobilanthes crispus,Orthosiphon stamineus和Stevia rebaudiana的最佳配方. 这样我们可以确定它们的最佳配方.
在配方中最大限度地提高和黄的总含量.
尽量减少IC50对于体外的丁氧化酶抑制活性.

主要方法:

热水输液被用来从选定的植物中提取植物化学物质.
使用Folin-ciocalteu和化试验量化总和黄含量.
评估了丁氧化酶抑制活性,并使用简单-中心混合物设计分析了配方.

主要成果:

选择了特定的模型来描述配方相互作用.
观察到低IC50值为13.90μg/mL的丁氧化酶抑制.
抗痛风活性与高的和黄类含量相关.

结论:

确定了 44.26% 的 Orthosiphon stamineus 和 55.74% 的 Stevia rebaudiana 的最佳配方.
这种配方在体外表现出显著的丁氧化酶抑制活性.
优化的多草药混合物显示出作为一种替代性痛风治疗的潜力.

关键词:

多草药配方多草药配方简单 - 中心混合物设计设计总的黄酸盐含量是多少的总含量的总含量克桑氧化酶抑制的抑制作用

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