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Updated: Jul 19, 2025

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
07:42

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

Published on: February 7, 2021

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布罗利祖马布在患有高瘤突变负担的瘤患者中:来自向药剂和分析利用注册表研究的结果

Herbert L Duvivier1, Michael Rothe2, Pam K Mangat2

  • 1Cancer Treatment Centers of America-Atlanta, Part of City of Hope, Newnan, GA.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology
|August 10, 2023
PubMed
概括

布罗利祖马布在晚期癌症患者中表现出抗瘤作用,这些患者具有高瘤突变负担 (HTMB). 这项针对性药物和分析利用注册表 (TAPUR) 试验中的研究在结肠直肠和其他晚期癌症队列中发现了疾病控制.

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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