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Updated: Jul 19, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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在B细胞淋巴瘤中,CARD11的功能增强调节了BCL2A1的表达,并促进了针对性治疗组合的耐药性

Salomé Decombis1, Celine Bellanger1, Yannick Le Bris2

  • 1Hematology Department, Nantes Université, INSERM, CNRS, Université d'Angers, CRCI2NA, Nantes, France.

Blood
|August 10, 2023
PubMed
概括

针对B细胞淋巴瘤的向疗法可以通过CARD11突变导致耐药性,导致NF-κB1激活. 与BCL2抑制相结合的MALT1抑制克服了这种抵抗,为攻击性B细胞淋巴瘤提供了新的治疗策略.

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