一个容易吞的药丸:为21世纪提供口服复合疫苗
Molly R Braun1, Becca A Flitter1, William Sun1
1Vaxart, Inc., 170 Harbor Way STE 300, South San Francisco, CA 94080, USA.
Current opinion in immunology
|August 10, 2023
概括
使用非复制性腺病毒5型载体的下一代口服疫苗显示出更强的粘膜免疫力. 这些复合腺病毒5型 (rAd5) 疫苗为流感和SARS-CoV-2等疾病提供了潜在的公共卫生益处.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 粘膜免疫对于防止病原体进入入口处至关重要.
- 目前的复合粘膜疫苗在临床试验中经常显示出弱或不一致的免疫性.
- 需要更多的免疫新一代粘膜疫苗.
研究的目的:
- 审查口服疫苗的临床进展情况.
- 强调下一代粘膜疫苗使用非复制的人类重组腺病毒5型 (rAd5) 载体.
- 讨论口服rAd5疫苗的免疫性,疗效,保护相关物和传播影响.
主要方法:
- 对口服rAd5疫苗的临床试验数据的审查.
- 针对流感,诺罗病毒和SARS-CoV-2的免疫性和疗效的综述.
- 讨论保护和疾病传播的相关性.
主要成果:
- 通过口服rAd5疫苗观察到积极的临床结果.
- rAd5 载体显示出诱导强大的免疫反应的潜力.
- 针对特定传染病的疗效和免疫原性数据.
结论:
- 通过先进的配方可以获得成功的口服疫苗接种.
- 不复制的rAd5载体代表了下一代粘膜疫苗的有希望的平台.
- 口服疫苗接种具有显著的公共健康益处潜力.
相关概念视频
Recombinant DNA
95.9K
Overview
95.9K
Microorganisms in Medicine and Therapeutics
54
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
54
Vaccinations
44.7K
Overview
44.7K
Cancer Vaccines
403
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
403
The Central Dogma
21.8K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
21.8K
Cross-reactivity
31.3K
Overview
31.3K


