大脑衍生的神经营养因子和精神分裂症患者对体力炼的神经认知反应之间的关系
Gry Bang-Kittilsen1, Jens Egeland2, Thor Ueland3
1Division of Mental Health and Addiction, Vestfold Hospital Trust, Tonsberg, Norway.
Psychoneuroendocrinology
|August 10, 2023
概括
脑衍生神经营养因子 (BDNF) 基线水平对精神分裂症患者的认知有适度的运动影响. 较高的基线BDNF预测了体力活动带来的更大的神经认知收益,解释了一些反应变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 运动生理学 运动生理学
背景情况:
- 身体炼显示了在精神分裂症中增强神经认知的潜力,可能是通过神经可塑性.
- 在对运动的神经认知反应中存在显著的个体间变异.
- 大脑衍生神经营养因子 (BDNF) 被假设为调解运动诱导的神经认知改善.
研究的目的:
- 调查边缘静止BDNF水平与精神分裂症患者对体力炼的神经认知反应之间的关系.
- 探索BDNF是否适度或调解运动对神经认知的影响.
主要方法:
- 一项随机对照试验 (RCT) 的二次分析,涉及82名精神分裂症患者.
- 参与者被随机分配到高强度间歇训练 (HIIT) 或主动视频游戏 (AVG) 12周.
- 调解和适度分析用于评估基线BDNF (成熟BDNF和proBDNF) 对神经认知结果的作用.
主要成果:
- 基线成熟的BDNF (mBDNF),但不是proBDNF,显著减轻了运动对神经认知的影响,解释了7%的差异.
- 较高的MBDNF基线水平与较大的神经认知改善有关.
- 干预后,无论运动类型如何,平均mBDNF水平都下降,而proBDNF水平保持稳定.
结论:
- 基线mbdfn水平在精神分裂症患者体育炼的神经认知益处中起到缓和作用.
- BDNF没有调解运动-认知关系,其在运动反应变化中的作用需要进一步阐明.
- 这些发现突出了个人差异的重要性,可能与BDNF有关,在为精神分裂症量身定制运动干预措施.
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