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过度表达HOXB8诱导下皮肤的形态变化:RNA-seq分析

Xiaotong Zheng¹, Ying Zhang², Yawen Zhang³

¹State Key Laboratory of Farm Animal Biotech Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, Jiangsu Province, China.

Poultry science

|August 10, 2023

概括

这项研究揭示,HOXB8基因调节了阳胡子的独特羽毛 (和胡子) 和的特征. 更高的HOXB8表达驱动了这些独特的品种特征.

科学领域:

* 鸟类遗传学和发育生物学.
* 动物表型变化的分子机制.

背景情况:

* 惠阳胡子表现出独特的面部羽毛 (嘴巴和胡子) 和短 (SW).
* 头和胡子 (Mb) 属性与下皮肤中homeobox B8 (HOXB8) 基因的上调相关.
*调节这些特征的分子通路在很大程度上仍未被描述.

研究的目的:

* 为了研究和胡子 (Mb) 和短 (SW) 的分子基础,在胡子.
*阐明HOXB8在调节这些表型变异中的作用.
* 识别参与羽毛和发育的基因.

主要方法:

*从Mb和野生类型的下皮肤和皮的转录组分析.
*基因表达特征分析,以比较Mb和野生类型组.
*DNA结合动机分析,以预测HOXB8的监管目标.

主要成果:

* 显著更高的HOXB8表达在Mb的下皮和皮中观察到.
* Mb 的下皮肤中的氨酸合成基因的升级,这表明它在羽毛发育中的作用.
* Mb 的 wattles 中细胞外基因基因的改变表达,可能会影响 SW 特性.
*确定直接和间接的HOXB8监管目标,包括新基因.

结论:

*HOXB8在调节惠阳胡子的Mb和SW表型方面发挥着至关重要的作用.
*HOXB8通过直接或间接的机制影响羽毛毛囊的发育和的生长.
* 结果提供了对鸟类皮肤附属物的变异和在家禽养殖中的潜在应用的见解.

关键词:

这就是HOXB8B.羽毛的变化羽毛的变化形态变异的形态变化波形长度波形长度波形长度

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