视网膜微血管密度和复杂性的关联与发生的冠状动脉心脏病
Yuechuan Fu1, Mayinuer Yusufu2, Yueye Wang3
1Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Atherosclerosis
|August 10, 2023
概括
视网膜微血管网络的复杂性和密度与冠心病 (CHD) 风险有关. 视网膜血管的复杂性和密度较低,可能预测发生心血管疾病的增加.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 医疗成像医学成像
背景情况:
- 冠状动脉心脏病 (CHD) 对全球健康造成重大负担,需要早期发现和干预策略.
- 视网膜微血管参数通过非侵入性 fundus 摄影和深度学习来量化,为风险评估提供了潜在的途径.
研究的目的:
- 调查视网膜微血管定量参数与发生冠心病 (CHD) 的风险之间的关联.
主要方法:
- 利用了英国生物库的数据,这些数据来自没有先前心脏病诊断的参与者.
- 采用深度学习系统提取视网膜微血管指标:碎形维度 (Df),血管段数 (NS),血管骨密度 (VSD) 和血管区域密度 (VAD).
- 使用多变量Cox比例危险模型分析数据,随访时间中位数为11.0年.
主要成果:
- 断层尺寸 (Df) 的减少,较低的动脉和静脉NS,以及动脉和静脉VSD的减少与发生性心脏病的风险增加显著相关.
- 该研究包括57,947名参与者,在随访期间记录了3211起发生的CHD事件.
- 特定危险比率表明了Df,NS (动脉和场地) 和VSD (动脉和场地) 的显著关联.
结论:
- 视网膜微血管参数与发生性心血管疾病之间存在显著的关联.
- 视网膜血管网络的复杂性和密度降低可能表明患心血管疾病的风险更高.
- 定量视网膜结构测量显示了增强CHD预测模型的前景.
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