在测试儿童生长激素水平时,耐火性的流行率
Camilla Borghammar1, Victoria Boije1, Charlotte Becker2
1Lund University, Skåne University Hospital, Department of Clinical Sciences, Pediatrics, Pediatric Endocrinology, Lund, Sweden.
概括
深夜生长激素 (GH) 脉冲可能会影响矮身儿童的检测结果. 很大一部分儿童对GH检测不耐药,这表明程序因素可能会影响结果.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 增长激素生理学 生理学
- 诊断测试 诊断测试 诊断测试
背景情况:
- 自发的夜间生长激素 (GH) 分泌模式可能会影响下垂体在挑性测试期间的反应.
- 了解这些影响对于患有生长障碍的儿童进行准确诊断至关重要.
研究的目的:
- 在短暂的自发性夜间特征 (SSNP) 中观察到的GH峰值之后,在氨酸-胰岛素耐受性测试 (AITT) 中评估GH反应.
- 为了确定影响GH测试短身或生长速度较低的儿童的折射率的因素.
主要方法:
- 对257名接受SSNP和AITT的儿童 (4-18岁) 的医疗记录进行了回顾性审查.
- 耐火儿童的定义是那些在SSNP期间但不是在AITT期间GH峰值≥7μg/L的儿童.
- 分析临床特征,测试之间的时间,以及医院间的变化.
主要成果:
- 在SSNP或AITT期间GH峰值的儿童中,21.9%被归类为耐火.
- 耐火儿童的男性比例更高,BMI标准偏差得分更高.
- 在AITT期间的最后一个夜间GH峰值和最大GH峰值之间的时间有所变化,非耐火病例的峰值较早.
结论:
- 显著比例的矮身儿童在GH测试中表现出折射性.
- 在耐火病例中,很少发现明显的临床特征.
- 程序变化可能会影响折射性,并且应在GH反应评估期间考虑.
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