性别与动脉样硬化斑块特征的关系通过不同的血管造影狭窄症严重程度
Rebecca Jonas1, Toral Patel2, Tami R Crabtree3
1Department of Internal Medicine, Yale New Haven Hospital, New Haven, Connecticut.
The American journal of cardiology
|August 10, 2023
概括
性别对冠状动脉疾病中的动脉硬化斑块特征 (APC) 有影响. 在非阻塞性病变中,男性显示出更低密度的非化斑块 (LD-NCP),而女性在阻塞性病变中显示出更多的化斑块 (CP).
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 动脉硬性斑块特征 (APC) 的性别特异性差异及其与狭窄症严重程度的关系尚不清楚.
- 了解这些差异对于个性化的心血管风险评估和治疗至关重要.
研究的目的:
- 为了调查性别是否影响冠状动脉狭窄的不同程度的APC.
- 为了在阻塞性和非阻塞性病变中比较性别之间的斑块组成.
主要方法:
- 在CREDENCE试验中,分析了303名症状患者的冠状动脉计算机断层血管学和侵入性冠状动脉血管学数据.
- 使用人工智能对APC进行定量分析,包括百分比动脉瘤体积 (PAV),低密度非化斑块 (LD-NCP),非化斑块 (NCP) 和化斑块 (CP).
- 病变的分类是阻塞性 (直径≥50%的狭窄) 或非阻塞性 (直径<50%的狭窄).
主要成果:
- 在阻塞性疾病中,男性的LD-NCP PAV更高,而女性的CP PAV更高.
- 在两种性别的阻塞性病变中,NCP PAV比非阻塞性病变更高.
- 与非阻塞性病变相比,患有阻塞性病变的女性的LD-NCP PAV和CP PAV较大.
- 根据性别比较阻塞性病变,女性患上CP PAV更多,男性患上NCP PAV更多.
- 与女性相比,男性在非阻塞性病变中有更多的LD-NCP PAV.
结论:
- 在动脉样硬化斑块的组成中存在显著的性别特异性差异,因狭窄症的严重程度而异.
- 这些发现强调了在评估和治疗冠状动脉样硬化时考虑性别的重要性.
- 需要进一步的研究来阐明这些观察到的基于性别的斑块差异的临床影响.
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