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创伤患者早期炎症标志物的预测值基于输血状态
Matthew R Baucom1, Taylor E Wallen1, Adam D Price1
1Department of Surgery, University of Cincinnati, Cincinnati, Ohio.
The Journal of surgical research
|August 10, 2023
概括
早期炎症标志物如IL-1ra,IL-8,IL-10和MCP-1可以预测严重受伤的创伤患者的30天死亡率. 这些标记物在受伤后6小时内有用,无论输血状态如何.
科学领域:
- 创伤重症监护中心的重症监护中心.
- 炎症生物标志物研究研究
- 在危急疾病中的预后建模.
背景情况:
- 七种炎症生物标志物以前与大量输血患者的死亡率有关.
- 早期识别创伤中的死亡风险因素对于及时干预至关重要.
研究的目的:
- 在所有严重受伤的创伤患者中确定预测30天死亡率的早期炎症标志物.
- 评估受伤后6小时内特定炎症标志物的预测值.
主要方法:
- 对238名创伤重症监护室患者进行的前性单中心研究.
- 在6,24小时和72小时分析了syndecan-1,eotaxin,IL-1ra,IL-6,IL-8,IL-10,IP-10和MCP-1的血清水平.
- 使用后勤回归来基于生物标志物和混因子的30天生存模型,包括对输血状态的子组分析.
主要成果:
- 在72小时内,非幸存者的IL-1ra,IL-8,IL-10和MCP-1显著升高.
- 在受伤后6小时增加的IL-1ra,IL-8,IL-10和MCP-1预测了30天的死亡率.
- 辛德坎-1和eotaxin水平与死亡率无关;在接受大量输血的非幸存者中,IL-8和乳酸盐升高.
结论:
- 在受伤6小时内对IL-1ra,IL-8,IL-10和IP-10的早期评估有效地预测了30天的死亡率.
- 输血状态没有显著影响这些早期炎症标志物的预测值.
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