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(III) -py2系统作为基于β-ketoester的配体的潜在载体

Marcos V Palmeira-Mello¹, Ana B Caballero², Piedad Herrera-Ramírez³

¹Departamento de Química, Universidade Federal de São Carlos (UFSCar), 13561-901 São Carlos, São Paulo, Brazil; Instituto de Química, Universidade Federal Fluminense, Outeiro S. João Batista S/N, 24020-141 Niterói, RJ, Brazil.; nanoBIC, Departament de Química Inorgànica i Orgànica, Secció Química Inorgànica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.

Journal of inorganic biochemistry

|August 10, 2023

概括

新的 (III) 复合物作为生物降解性产药. 在生物条件下,它们释放出活性β-基托配体,显示出药物输送平台的潜力.

科学领域:

无机化学无机化学
药用化学医学化学
生物化学生物化学

背景情况:

(III) 复合物被探索为潜在的生物降解性前药物.
新型药物输送系统的开发对于向治疗至关重要.

研究的目的:

合成和描述两种新的 (III) 复合物与β-基托连接体.
调查它们作为生物减少前药物和DNA相互作用剂的潜力.
评估它们作为提供生物活性化合物的平台的适用性.

主要方法:

使用红外光谱学,CHN元素分析,NMR光谱学和ESI质谱学合成和描述 (III) 复合物.
用X射线衍射分析来阐明一个复杂的结构.
氧化还原特性分析,以评估适用于生物还原的适度.
DNA 相互作用研究.
在体外试验中使用亚斯科布酸进行研究,以调查连接体释放的情况.

主要成果:

两种 (III) 复合物[Co (L1) (py2en) ] (ClO4) 2·H2O和[Co (L2) (py2en) ] (ClO4) 2已成功合成和表征.
氧化还原特性证实了在生理条件下适合减少的特性.
复合物通过静电相互作用与DNA结合.
与 Askorbic 酸的反应导致 β-ketoester 配体的释放,这表明了生物还原性激活.

结论:

合成的 (III) 复合物显示出作为生物修复性前药物的前景.
它们在减少时释放β-基托配体的能力使它们成为药物输送的潜在平台.
需要进一步的研究来探索它们的治疗应用.

关键词:

抗癌药物抗癌药物抗癌药物 (III) 复合物的复合物结合 DNA 的 DNA 结合.低氧激活的药物递送是低氧激活的药物递送.它们是前药物.在β-基托埃斯特.

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