在堆肥中抗生素耐药性基因的风险评估和传播机制
Yifei Xu1, Lin Zhu1, Shanguo Chen1
1Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-saving Fertilizers, Nanjing Agricultural University, Nanjing 210095, China.
Environment international
|August 10, 2023
概括
堆肥显著减少了牲畜中的抗生素耐药基因 (ARG),降低了环境风险. 建议在无抗生素的养殖中控制ARG的演变和源头传播.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 农业科学 农业科学
背景情况:
- 在牲畜中过度使用抗生素会导致便中的抗生素耐药基因 (ARG).
- 堆肥是一种肥料管理策略,有可能减少ARG,但完全消除是困难的.
- 之前的研究可能错误地判断了ARG风险,因为它们侧重于多样性和丰富性,而不是转移潜力.
研究的目的:
- 调查堆肥中ARG的转移潜力.
- 分析ARG与堆肥中的机会性病原体的同时发生情况.
- 使用元基因组数据评估堆肥中ARG的全球风险.
主要方法:
- 全球堆肥基因组测序数据的广泛分析.
- 对ARG转移潜力的调查.
- 检查ARG与致病细菌的同时发生.
主要成果:
- 与肥相比,堆肥显著降低了ARG的潜在风险.
- 微生物群落适应抗生素压力,有利于ARG传播.
- 在堆肥和肥中的代谢相互作用主要由抗生素耐药的微生物主导.
结论:
- 堆肥是一种有效的策略,可以减轻来自牲畜物的ARG风险.
- 没有抗生素的养殖实践对于控制ARG进化和传播至关重要.
- 通过减少抗生素来控制源是减少ARG的关键.
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