在中风中出现胃肠道功能障碍
Heather Y F Yong1,2, Aravind Ganesh1,2, Carlos Camara-Lemarroy1,2
1Department of Clinical Neurosciences, University of Calgary, Calgary, Canada.
Seminars in neurology
|August 10, 2023
概括
缺血性中风幸存者经常经历胃肠道 (GI) 并发症. 这篇评论探讨了肠-大脑轴,肠道失调,以及中风患者的新疗法.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 超过50%的缺血性中风幸存者发展胃肠道 (GI) 并发症,包括消化不良,便秘和出血.
- 肠-大脑轴和中风之间存在双向关系,其中中风会诱导肠道失调,失调会使神经结果恶化.
- 来自肠道的促炎细胞和肠道代谢物与中风后的肠-大脑轴功能障碍有关.
研究的目的:
- 审查在急性缺血性中风中已知的胃肠道并发症.
- 用实验模型总结目前关于中风中肠-大脑轴功能障碍的知识.
- 讨论针对肠-大脑轴的新兴治疗方法.
主要方法:
- 关于胃肠道中风后的并发症现有研究的文献综述.
- 对实验性中风模型的分析,调查肠-大脑轴的变化.
- 对肠-大脑轴调节的新型治疗策略的研究综合.
主要成果:
- 脑卒中与显著的胃肠道并发症和肠道失调症有关.
- 肠道失调有助于通过肠-大脑轴功能障碍导致功能性神经学结果差.
- 来自肠道的炎症前驱细胞和代谢物可能会调解这种功能障碍.
结论:
- 了解肠-大脑轴对于管理中风恢复至关重要.
- 准肠道微生物组为中风提供了潜在的新治疗途径.
- 对肠-大脑轴干预的进一步研究可能会改善中风幸存者的功能结果.
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