基于酸盐的纳米凝载体的设计和开发,用于以太化物输送
Gülcan Geyik1, Enes Güncüm2, Nuran Işıklan3
1Department of Chemistry, Faculty of Arts and Sciences, Kırıkkale University, Yahşihan, 71450 Kırıkkale, Turkey; Alaca Avni Çelik Vocational School, Hitit University, Çorum, Turkey.
International journal of biological macromolecules
|August 10, 2023
概括
新的pH响应性酸纳米凝增强了用于癌症治疗的酸输送. 这些纳米凝提供了可控的药物释放和改善的抗癌疗效,显示了针对性治疗的希望.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 响应pH的纳米凝对于先进的癌症疗法至关重要.
- 需要有控制的药物释放系统来提高埃托波西德的疗效和减少副作用.
研究的目的:
- 设计和开发适应pH值的酸盐基纳米凝,用于化物 (Et) 输送.
- 为了增强水友性和控制释放的埃托.
- 评估开发的纳米凝的抗癌疗效和生物相容性.
主要方法:
- 通过微波支持的合成与2-基甲胺 (HPMA) 接种基酸盐 (ALG),形成ALG-g-PHPMA.
- 使用乳液方法制造纳米凝.
- 使用包括NMR,FTIR,TG/DSC,AFM/TEM,BET和DLS在内的技术进行表征.
- 在肺癌细胞上的体外药物释放研究和细胞毒性测定.
主要成果:
- 实现了埃托胺的高封装效率 (79.60%).
- 与赤裸的酸盐纳米凝相比,已经证明pH取决于和在体外加速释放以托化物.
- 提高了酸盐纳米凝的稳定性,表面积和多孔性.
- 与自由乙烯相比,ALG-g-PHPMA纳米凝显示出高生物相容性和对H1299肺癌细胞的优异抗癌作用.
结论:
- 开发的ALG-g-PHPMA纳米凝作为一种有效的pH依赖的纳米平台,用于以太化物输送.
- 该系统通过有针对性和可控的药物释放提供了改善癌症治疗的潜力.
- 纳米凝的增强稳定性和生物相容性支持它们的临床适用性.
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