一个多中心集群随机控制临床试验的结果,测试生物信息学支持的药剂师干预在移植受体中的有效性
David J Taber1, Ralph C Ward2, Casey H Buchanan3
1Department of Pharmacy Services, Ralph H Johnson Veterans Affairs Medical Center, Health Equity and Rural Outreach Innovation Center, Charleston, South Carolina, USA; Division of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
概括
门诊护理的新药物安全仪表板减少了移植患者的急诊室访问和住院. 这种由药剂师主导的干预措施提高了患者的安全性,特别是在低风险人群中.
科学领域:
- 医疗信息学 医疗信息学
- 药理学 药理学是指药理学的学科.
- 患者安全 患者安全
背景情况:
- 门诊药物的安全性是一个日益关注的问题,特别是在移植接受者.
- 在门诊环境中识别和减轻与药物相关的风险是一项挑战.
- 现有的系统往往缺乏全面的工具来主动监测药物安全.
研究的目的:
- 为了评估新型门诊药物安全仪表板的有效性.
- 评估药剂师主导干预使用这个仪表板对患者结果的影响.
- 确定仪表板干预是否减少了急诊室 (ED) 的访问和住院.
主要方法:
- 这是一项为期两年的前性,集群随机化,受控的多中心研究.
- 在5个干预地点的药剂师使用药物安全仪表板.
- 与5个对照地点的通常护理进行比较,包括2196个移植事件.
主要成果:
- 干预组显示ED访问的绝对风险降低11.3%,住院的绝对风险降低12.3%.
- 两种结果的P<0.001,表明统计学意义.
- 治疗效果因患者的风险因素和移植类型而异.
结论:
- 一个能够使用仪表板的,由药剂师领导的干预措施显著减少了外科医院移植患者的急救诊所访问和住院治疗.
- 该干预措施显示出有效性,特别是在低风险患者群体中.
- 这种方法突出了健康信息学工具在提高药物安全性和患者护理方面的潜力.
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