与过往心血管事件相关的信号通路在高伤性心肌病症中
Charlotte Lee1, Lusha W Liang1, Kohei Hasegawa2
1Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
Journal of cardiac failure
|August 10, 2023
概括
这项研究在使用蛋白质组学的高性心肌病 (HCM) 患者中发现了与主要不良心血管事件 (MACE) 相关的新分子途径. 这些发现促进了对HCM进展和风险分层的理解.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 增高性心肌病变 (HCM) 是一种常见的遗传性心脏病.
- 显著的一小部分HCM患者经历了主要的不良心血管事件 (MACE),如心律失常,中风和心力衰竭.
- 在HCM中MACE的分子驱动因素仍然不完全理解.
研究的目的:
- 在HCM患者中识别与MACE相关的失调信号通路.
- 为了利用等离子体蛋白质组学分析进行发现.
- 为了比较有和没有MACE病史的患者.
主要方法:
- 一项多中心病例控制研究,涉及402名HCM患者.
- 4986种蛋白质的等离子体蛋白质组学分析.
- 为MACEs开发和外部验证基于蛋白质组学的歧视模型.
主要成果:
- 开发的模型显示出强大的预测性能 (测试组中的AUC为0.82).
- 以前患有MACE的患者表现出失调的通路,包括已知的通路,如TGF-β和新的通路,如Ras-MAPK.
- 蛋白质组学确定了独特的分子特征,区分了有或没有MACE的HCM患者.
结论:
- 这项研究成功地确定了MACEs的HCM患者的既定和新型失调途径.
- 这些发现有助于更深入地了解在高级HCM中MACEs背后的分子机制.
- 蛋白质组学分析为识别HCM风险因素和潜在治疗点提供了一个有前途的途径.
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