上部胃肠道癌症的能量消耗:一个范围审查
Lauren Hanna1, Judi Porter1, Judy Bauer2
1Department of Nutrition, Dietetics and Food, Monash University, Clayton, Victoria, Australia; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.
Advances in nutrition (Bethesda, Md.)
|August 10, 2023
概括
在上胃肠道癌症患者中,营养不良很常见. 目前用于估计能源需求的方法是不准确的,强调了需要在临床实践中直接测量能源消耗的必要性.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 代谢过程中的代谢.
背景情况:
- 营养不良显著影响上部胃肠道 (GI) 癌症患者的生存率和生活质量.
- 准确的能源供应对于营养干预来打击营养不良至关重要.
- 现有的能源需求预测方程在癌症群体中通常是不准确的.
研究的目的:
- 系统地审查和综合有关上部肠道癌症患者能量消耗的现有证据.
- 确定用于测量这一患者群体的能源消耗的方法.
主要方法:
- 对三个主要数据库 (Ovid MEDLINE,Embase,CINAHL plus) 的综合范围审查.
- 包含原始研究研究,测量休息能量消耗 (间接热量计) 或总能量消耗 (双重标记的水) 在成年人上部肠道癌症.
- 分析了57项符合条件的研究,涉及2,125名参与者,涉及各种上部肠道癌症类型.
主要成果:
- 能源支出数据主要来自间接热量计,其中一项研究使用双重标记的水.
- 报告的能源支出在癌症类型内和癌症类型之间有很大差异.
- 观察到研究设计和临床特征报告的异质性.
- 19项研究将能源消耗与非癌症对照进行了比较,31项研究将测量与预测值进行了比较.
结论:
- 对上部肠道癌症患者的能量需求的预测方程是不可靠的,原因是显著的异质性和不准确性.
- 在临床实践中,只要可行,就建议直接测量能源消耗.
- 需要进一步的研究,以根据特定的癌症类型,阶段和治疗方法精确地描述能量消耗.
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