针对因果推断的目标试验模拟的实施:一个范围审查
Hanxiao Zuo1, Lin Yu1, Sandra M Campbell2
1School of Public Health, University of Alberta, Edmonton, Alberta T6G 1C9, Canada.
Journal of clinical epidemiology
|August 10, 2023
概括
目标试验模拟 (TTE) 越来越多地用于健康研究中的因果推断. 然而,不一致的应用和报告问题凸显了需要改善对TTE框架的遵守.
科学领域:
- 观察数据的分析分析.
- 因果推理方法论的因果推理方法.
- 卫生研究应用健康研究应用.
背景情况:
- 目标试验模拟 (TTE) 是因果推理的一个关键策略.
- 越来越多的人对TTE感兴趣,以分析观察健康数据.
- 需要标准化的TTE实施和报告.
研究的目的:
- 调查TTE在健康研究中的实施情况.
- 确定共同的TTE战略和挑战.
- 确定TTE框架改进的领域.
主要方法:
- 根据JBI和PRISMA-ScR指南进行范围审查.
- 卫生研究图书馆员进行全面的文献搜索.
- 由两个独立审查员进行选和数据提取.
主要成果:
- 确定了1240篇论文,其中96篇用于数据提取.
- 在2018-2021年期间,TTE出版物的显著增加.
- 主要研究领域:癌症,心血管和传染病.
- 对关键TTE组件的不一致报告 (零时间,随机分配模拟,比较策略).
- 常见的局限性:剩余的混,概括性,缺乏报告指导.
结论:
- 遵守TTE框架是不均的.
- 未来的改进对于使用观测数据进行可靠的因果推断至关重要.
- 需要加强TTE指导来推进研究.
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