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相关概念视频

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Randomized Experiments01:13

Randomized Experiments

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The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
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Regression Toward the Mean01:52

Regression Toward the Mean

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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Blinding01:11

Blinding

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Blind Procedures02:07

Blind Procedures

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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相关实验视频

Updated: Jul 19, 2025

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
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在176,469个随机对照试验中,方法报告随着时间的推移而得到改善.

Halil Kilicoglu1, Lan Jiang1, Linh Hoang1

  • 1School of Information Sciences, University of Illinois Urbana-Champaign, Champaign, IL, USA.

Journal of clinical epidemiology
|August 10, 2023
PubMed
概括

随机对照试验 (RCT) 报告随着时间的推移而得到改善,关键方法的文档增加. 然而,诸如分配隐藏等领域需要进一步改进,以提高试验透明度和可重复性.

关键词:
一个士的士.机器学习是机器学习.超级研究的研究.随机对照试验是随机对照试验.报告准则 报告准则文本挖掘 (Text Mining) 是一种文字挖掘方式.

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科学领域:

  • 临床试验方法论 临床试验方法论
  • 研究诚信研究诚信
  • 基于证据的医学基于证据的医学.

背景情况:

  • 随机对照试验 (RCT) 报告的质量对于评估研究有效性和可重复性至关重要.
  • 报告试验综合标准 (CONSORT) 声明提供了关于RCT报告最低要求的基本准则.
  • 了解RCT报告的历史趋势可以确定需要改进的领域.

研究的目的:

  • 量化描述随着时间的推移,RCT方法报告的演变.
  • 评估期刊影响因子和医学纪律对报告趋势的影响.
  • 确定持续报告缺陷的特定CONSORT项目.

主要方法:

  • 使用CONSORT语句开发了一个基于深度学习的句子分类模型.
  • 分析了1966年至2018年间发表的176,469份RCT报告.
  • 报告趋势在5年期间进行了检查,分析按期刊影响因子和医学学科分层.

主要成果:

  • 报告人口,干预,比较,结果 (PICO) 项目和干预措施通常随着时间的推移而增加.
  • 在序列生成报告中观察到显著改善 (10.8%至41.8%),但分配隐藏仍然不常见 (5.1%至19.3%).
  • 报道的项目数量与期刊影响因子的相关性很弱,医学学科之间的差异很小.

结论:

  • 大规模的定量数据支持这一假设,即RCT方法报告得到了改进.
  • 扩展基于CONSORT项目的自动报告检查可以帮助手稿撰写和同行评审.
  • 这些发现支持使用此类模型来促进合规性和推进metaresearch.