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基于针的共聚焦激光内显微镜用于实时颗粒瘤检测

Tess Kramer¹, Lizzy Wijmans¹, Saskia van Heumen¹

¹Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Respirology (Carlton, Vic.)

|August 10, 2023

概括

基于针的共聚焦激光内分显微镜 (nCLE) 现在可以实时识别颗粒瘤. 盲目评分器准确地区分了nCLE颗粒瘤标准与恶性瘤,改善了肺结节分析.

科学领域:

医疗成像医学成像
胃肠病学胃肠病学
肺部病理学肺部病理学

背景情况:

基于针的共聚焦激光内分显微镜 (nCLE) 提供了针尖的实时显微镜成像.
目前的nCLE恶性瘤标准有助于支气管镜肺结节的分析,但对颗粒瘤的标准不存在.
这项研究旨在定义和验证颗粒瘤的nCLE标准.

研究的目的:

为了确定和验证颗粒瘤的nCLE标准.
评估盲目的评分人员在恶性和粒状nCLE发现之间区分的能力.
提高nCLE在肺结节分析中的诊断效用.

主要方法:

在内镜超声波期间,在怀疑患有沙尔科毒症的患者中,对中淋巴结的nCLE成像.
通过将成像与病理学和最终诊断相关联来确定nCLE颗粒瘤标准.
通过盲目评定者对nCLE视频进行验证,以确定分辨颗粒瘤与恶性瘤的准确性和可靠性.

主要成果:

在14名肉类瘤患者中,确定了nCLE颗粒瘤标准 (更明亮的,均的,清晰划分的病变).
评级人员在淋巴结nCLE视频中识别颗粒瘤标准时达到88%的准确性,具有相当大的观察者间 (κ=0.63) 和观察者内部 (κ=0.70) 可靠性.
在肺结节中,nCLE以92%的准确度正确识别了颗粒瘤,并以75%的准确度识别了恶性瘤.

结论:

nCLE可以实时可视化和识别颗粒瘤.
盲定评分人员在识别nCLE颗粒瘤标准方面表现出高准确度和一致性,将其与恶性瘤区分开来.
nCLE显示出作为指导肺结节分析的实时工具的巨大潜力.

关键词:

支气管镜检查和干预技术.细胞科学细胞学组织学组织学 nCLE nCLE nCLE nCLE nCLE nCLE nCLE nCLE nCLE nCLE nCLE nCLE nCLE 基于针的共聚焦激光内微镜.放射学和其他成像学.实时检测颗粒瘤的检测这种类型的麻症是有毒的.

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