免疫学和微生物组:对运动系统的影响
Yasamin Mahjoub1, Davide Martino2
1Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Handbook of clinical neurology
|August 10, 2023
概括
免疫和肠道健康与神经退行性运动障碍 (如帕金森病和ALS) 有关. 研究还探索了神经发育障碍中的这些联系,提出了新的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 神经炎症和免疫系统失调与运动神经元疾病 (如帕金森病和肌缩性侧面硬化症) 有关.
- 肠道微生物群的不平衡,即肠道失调,越来越多地被认为是导致这些神经退行性疾病的一个因素.
- 新出现的证据表明,免疫系统的参与和肠道失调也可能在像图雷特综合征这样的神经发育障碍中发挥作用.
结论:
- 免疫-炎症机制和肠道失调是运动神经退行性疾病的关键因素.
- 对肠-大脑轴的进一步研究是有必要的,以了解和潜在地治疗神经发育障碍.
- 针对神经炎症和肠道微生物组为一系列神经疾病提供了有前途的治疗途径.
相关概念视频
Microorganisms in Medicine and Therapeutics
54
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
54
Enteric Nervous System: Regulation of GI Motor Activity
458
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
458
Introduction to Lymphatic and Immune System
2.8K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
2.8K
What is the Immune System?
111.8K
Overview
111.8K
Immunological Memory
669
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
669
Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K


