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相关概念视频

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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相关实验视频

Updated: Jul 19, 2025

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

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自身免疫性多神经病变 自身免疫性多神经病变

Ryan Naum1, Kelly Graham Gwathmey2

  • 1Department of Neurology, Virginia Commonwealth University, Richmond, VA, United States.

Handbook of clinical neurology
|August 10, 2023
PubMed
概括
此摘要是机器生成的。

本章回顾了免疫媒介运动神经病变,不包括AIDP和CIDP. 这些自身免疫性疾病的早期诊断和治疗改善了患者的治疗结果.

关键词:
抗MAG神经病变是一种神经病变.糖尿病性氨缩症 糖尿病性氨缩症远端的CIDP是什么意思脊椎神经神经病变 - 脊椎神经神经神经神经神经神经神经神经神经神经神经神经神经神经神经神经神经单克隆性胃病变是一种病变.多焦点运动神经病变神经性氨缩症的神经性氨缩症帕索纳奇特纳综合征类风湿性血管炎是一种类风湿性血管炎.斯乔格伦的神经病变 (Sjogren's neuropathy) 是一种神经病变.

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相关实验视频

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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
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Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
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科学领域:

  • 神经学 神经学
  • 免疫学 免疫学 免疫学
  • 周围神经系统疾病 周围神经系统疾病

背景情况:

  • 带有运动症状的自身免疫外围神经病变多样化,存在于各种临床环境中.
  • 本综述侧重于免疫介导,运动主导的神经病变,不包括急性炎症性脱髓性多基基隆性神经病变 (AIDP) 和慢性炎症性脱髓性多基隆性神经病变 (CIDP).

研究的目的:

  • 要突出常见的免疫介导,运动主导的神经病变.
  • 讨论获得的脱髓化神经病变,根基复合神经病变以及与类风湿病相关的疾病.
  • 强调早期识别和治疗对改善结果的重要性.

主要方法:

  • 文献综述和综合有关免疫媒介运动神经病的当前知识.
  • 神经病变的分类包括远端CIDP,多焦点运动神经病变,根基复合神经病变 (糖尿病和非糖尿病的腰部神经骨质根基复合神经病变,神经动脉缩/帕森奇-特纳综合征),以及与Sjögren综合征和类风湿性关节炎相关的神经病变.

主要成果:

  • 识别和描述了AIDP和CIDP以外的关键免疫媒介运动神经病变.
  • 详细介绍了诸如多焦点运动神经病变,根结复合神经病变以及与类风湿病相关的具体疾病.
  • 强调了这些独特的神经病变的临床谱和诊断考虑因素.

结论:

  • 早期识别运动占主导地位的自身免疫神经病变至关重要.
  • 启动免疫调节和免疫抑制疗法可能会改善临床结果.
  • 了解这种多样化的神经病变群体有助于及时有效的患者管理.