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相关概念视频

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

17
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

9
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
9
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

112
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
112
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

16
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
16
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

291
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
291
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

148
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
148

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相关实验视频

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Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
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急性/慢性炎症性多根基隆性神经病变.

Caroline Miranda1, Thomas H Brannagan1

  • 1Department of Neurology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, United States.

Handbook of clinical neurology
|August 10, 2023
PubMed
概括

自身免疫性神经病变,包括吉兰-巴雷综合征 (GBS) 和慢性炎症性脱髓化多基原蛋白神经病变 (CIDP),存在不同的症状和免疫路径. 对这两种情况都采用了治疗策略,尽管反应可能不同.

科学领域:

  • 神经学 神经学
  • 免疫学 免疫学 免疫学
  • 病理学 病理学 病理学

背景情况:

  • 自身免疫性神经病变包括急性和慢性形式,包括吉兰-巴雷综合征 (GBS) 和慢性炎症性脱髓化多基基隆神经病变 (CIDP).
  • 这些疾病的特点是对外围神经的免疫中介损伤,呈现出从快速发作到逐渐进展的各种临床过程.
  • 虽然GBS通常是后传染性的,但CIDP的病原发生不明,尽管两者都涉及复杂的免疫路径.

研究的目的:

  • 确定急性和慢性自身免疫神经病变的临床表现和潜在的免疫机制.
  • 突出这些条件的诊断方法和可用的工具.
  • 讨论自身免疫性神经病变中的治疗策略和差异性治疗反应.

主要方法:

  • 基于特征性症状的临床诊断,如渐进的软弱,感官丧失和反射减弱.
  • 利用诊断工具来确认,预测和识别变体形式或模仿.
  • 评估免疫系统的参与,包括先天性和适应性途径.

主要成果:

  • 急性炎症性脱髓化多基基隆性神经病变 (GBS的亚型) 通常表现为快速,对称的软弱和感官丧失.
  • 慢性炎症性脱髓化多基原蛋白神经病变 (CIDP) 具有临床相似之处,但至少在8周内逐渐发病.
关键词:
在AIDPP的帮助下.急性炎症性去美色化多基原蛋白神经病变.在CIDP中,我们可以看到.慢性炎症性去髓化的多基基隆隆性神经病变.总体支付系统 (GBS) 是一个.吉兰·巴雷综合征 吉兰·巴雷综合征炎症性神经病变是一种神经病变.

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  • 这两种疾病都是由免疫路径驱动的,需要免疫抑制和免疫调节治疗,治疗结果各不相同.
  • 结论:

    • 自身免疫性神经病变是多种多样的,需要用诊断工具支持的仔细的临床诊断.
    • 了解特定的免疫通路对于管理这些疾病至关重要.
    • 虽然GBS和CIDP都有治疗方法,但它们的疗效可能有所不同,这强调了需要量身定制的治疗方法.