相关实验视频

Updated: Jul 19, 2025

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

推进结直肠免疫瘤学的转化研究

Elaine M Thomas¹, Josephine A Wright², Stephen J Blake²

¹Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.

British journal of cancer

|August 10, 2023

概括

结直肠癌 (CRC) 的临床前模型对于开发免疫检查点抑制剂 (ICI) 至关重要. 本综述评估了当前的小鼠模型,以提高CRC免疫疗法响应率.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
翻译研究是翻译研究.

背景情况:

结肠直肠癌 (CRC) 是一个重大的健康负担,免疫检查点抑制剂 (ICI) 在大多数患者中有效性有限.
患有DNA不匹配修复缺陷 (dMMR) 和微卫星不稳定 (MSI) CRC的患者表现出更好的ICI反应,但可靠的预测因素很少.
开发新的战略来加强ICI响应并克服CRC中的阻力仍然是一个至关重要的未满足需求.

研究的目的:

审查CRC免疫调节策略的临床前测试现状.
批判性地评估现有的小鼠模型在预测ICI临床反应中的有用性.
确定在临床前模型中需要改进的关键领域,以加快CRC的治疗开发.

主要方法:

在免疫治疗研究中使用的临床前CRC模型的系统审查.
分析常用的小鼠模型:化学诱导,移植和转基因.
评估模型的局限性和优势,以回顾人类的CRC和免疫反应.

主要成果:

现有的CRC小鼠模型在充分代表人类疾病复杂性和预测ICI疗效方面存在局限性.
化学诱导,移植和转基因模型提供了明显的优势,但也存在重大缺陷.
需要更复杂的模型,更好地模仿患者特定的瘤微环境和免疫相互作用.

结论:

改善临床前模型对于推进CRC免疫疗法至关重要.
整合来自患者的数据和开发新的先进模型是关键的步骤.
优化临床前测试将加速将研究成果转化为有效的CRC治疗方法.

更多相关视频

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer

Published on: July 18, 2017

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...