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Updated: Jul 19, 2025

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马洛尼尔-CoA是一种保存的内源ATP竞争mTORC1抑制剂

Raffaele Nicastro1, Laura Brohée2, Josephine Alba1

  • 1Department of Biology, University of Fribourg, Fribourg, Switzerland.

Nature cell biology
|August 10, 2023
PubMed
概括

哺乳动物/机械点的拉巴素复合物1 (mTORC1) 活性是由脂肪酸合成中间体malonyl-CoA直接抑制的. 这一发现揭示了一种保存的机制,将脂质生物合成与细胞生长调节联系起来.

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