相关实验视频
Updated: Jul 19, 2025

07:05
Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
Published on: September 8, 2021
2.4K
记住食物和敌人:转录记忆的新兴原则
Sahar S H Tehrani1, Anna Kogan1, Pawel Mikulski2
1Department of Biochemistry, University of Oxford, OX1 3QU, Oxford, UK.
Cell death and differentiation
|August 10, 2023
概括
细胞可以通过转录记忆记住过去的环境信号,这是一个在重新暴露时改变基因表达的原始状态. 这种细胞记忆有助于适应,对于像训练免疫力这样的过程至关重要.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 细胞生物学 细胞生物学
背景情况:
- 转录记忆涉及一个由外部刺激启动的细胞状态.
- 在刺激停止后,这种原始状态在细胞分裂中被遗传性地维持.
- 它使细胞能够记住外部信号以适应植物和哺乳动物的情况.
研究的目的:
- 审查原始化现象和对转录记忆的当前理解.
- 探索细胞记忆如何运作的机械模型.
- 讨论潜在的分子载体和转录记忆的适应性作用.
主要方法:
- 审查现有的关于转录记忆的文献.
- 分析用于记忆维护的机械模型.
- 关于分子签名和记忆载体的证据的讨论.
主要成果:
- 转录记忆在重新刺激时涉及改变的基因表达.
- 关键的分子签名包括平衡的RNA聚合酶II,基因素修饰和改变的染色质相互作用.
- 这种现象在各种各样的生物和刺激中观察到.
结论:
- 转录记忆是一个基本的生物过程,使细胞适应.
- 潜在的载体包括表观遗传修饰和染色质结构.
- 它起到适应性作用,从营养感应到训练免疫力.
相关概念视频
Immunological Memory
669
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
669
Implicit Memories
152
Implicit memories, also known as non-declarative memories, are long-term memories that function outside of conscious awareness. These memories influence behavior and skills without explicit knowledge. This type of memory is evident in tasks like playing tennis, snowboarding, and texting. Implicit memory has three subsystems: procedural memory, conditioning, and priming. This type of memory is essential in various activities, from everyday tasks to specialized skills.
One key aspect of implicit...
One key aspect of implicit...
152
Role of Neurotransmitters in Memory
628
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
628
Cells of the Adaptive Immune Response
1.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
1.0K
Higher Mental Functions of Brain: Learning and Memory
876
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
876
Long-Term Memory
200
Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
200

