临主导的与年龄相关的TDP43脑病变 (LATE) 神经退行性疾病中的神经病理变化
Sukriti Nag1, Julie A Schneider2
1Rush Alzheimer's Disease Center, Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA. Sukriti_Nag@Rush.edu.
Nature reviews. Neurology
|August 10, 2023
概括
边缘关联的TDP43蛋白脑病变 (LATE) 是一种类似于阿尔茨海默病 (AD) 的痴呆症. 研究重点是LATE神经病理变化 (LATE-NC),其病理学,以及开发诊断生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
- 老年病的医生 老年病的医生
背景情况:
- 塔尔DNA结合蛋白43 (TDP43) 病理学与各种神经退行性疾病有关.
- 临主导的与年龄相关的TDP43脑病变 (LATE) 是一种独特的痴呆实体,其特征是临区域的TDP43蛋白聚合.
- 晚期神经病理变化 (LATE-NC) 经常与阿尔茨海默氏症 (AD) 病理学同时发生.
研究的目的:
- 审查与LATE-NC相关的病理学,遗传风险因素和认知障碍.
- 突出在临床上将LATE与AD痴呆症区分开来的挑战.
- 强调需要开发LATE的诊断生物标志物.
主要方法:
- 对TDP43蛋白病变和LATE.现有文献的综述.
- 对LATE-NC中神经病理发现的分析,包括共存的病理.
- 讨论LATE的临床和认知概况及其与AD的关联.
主要成果:
- 晚期NC涉及TDP43积累主要在边缘区域,通常与AD病理共存.
- 纯LATE-NC和LATE-NC与共存的病理存在,存在类似AD的记忆障碍痴呆症.
- 根据临床表现来区分LATE和AD痴呆症是具有挑战性的.
结论:
- 晚期是老年人痴呆症的重要原因,特别是80岁以上的老年人.
- 开发特定的生物标志物对于准确的LATE临床诊断至关重要.
- 对于未来的治疗策略来说,对LATE-NC病变的进一步研究至关重要.
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