在患有喘和没有喘的青少年中,手握强度与依赖于努力的肺功能指标有关
Laura Marie Hesselberg1, Julie Nyholm Kyvsgaard1,2, Jakob Stokholm1,2,3
1COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Scientific reports
|August 10, 2023
概括
手握强度 (HGS) 与青少年的FEV1和FVC等肺功能指标相关. 虽然不特定于喘,但HGS增强了FEV1预测的准确性,这表明喘诊断的潜力.
科学领域:
- 肺部医学 肺部医学
- 诊断工具 诊断工具
- 青少年健康 青少年健康
背景情况:
- 手握强度 (HGS) 与肺功能 (FEV1) 有关,但其在喘病理生理学和诊断中的作用尚不清楚.
- 了解这种关联对于完善喘评估和管理策略至关重要.
研究的目的:
- 为了研究HGS和青少年肺功能指标之间的关系.
- 确定HGS在诊断喘和改善肺功能预测方面的实用性.
主要方法:
- 对330名青少年 (COPSAC2000队列) 的分析,评估了HGS,螺旋计 (FEV1,FVC,MMEF,FEV1/FVC),呼吸道阻力 (sRaw),甲荷林反应性 (PD20) 和部分呼出的氧化 (FeNO).
- 根据年龄,身高和体重进行调整的统计模型,以评估关联和预测能力.
主要成果:
- 在两种性别中,HGS与1秒内强制呼气体积 (FEV1) 和强制生命能力 (FVC) 有积极的关联.
- HGS使FEV1预测模型的准确性提高了2-5%,但没有提高喘状态分类.
- 没有发现HGS与呼吸道阻力,反应性或炎症之间有显著的关联.
结论:
- 在健康的青少年中,HGS与依赖于努力的肺功能指标 (FEV1,FVC) 相关,但与喘特异性标志物无关.
- HGS显示了提高FEV1估计准确度的潜力,为其在喘诊断中的应用提供了进一步的研究.
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