皮质星球细胞通过调节突触刺激和抑制平衡来调节雄性小鼠的支配行为
Kyungchul Noh1, Woo-Hyun Cho1, Byung Hun Lee2
1Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
Nature neuroscience
|August 10, 2023
概括
在雄性小鼠中,dorsomedial前额叶皮层的星体细胞双向地控制社会支配和层次结构. 这些质细胞调节神经元活动平衡,通过天体细胞-神经元通信影响社会地位.
科学领域:
- 神经科学是一个神经科学.
- 质生物学 质生物学
- 社会行为 社交行为
背景情况:
- 社会层次结构是从个人社会行为中产生的,比如统治.
- 星球细胞对于平衡神经元激发和抑制 (E/I),影响社会行为至关重要.
- 前额叶皮质天体细胞在主导行为中的特定作用仍然在很大程度上是未知的.
研究的目的:
- 研究dorsomedial前额叶皮层 (dmPFC) 星体细胞在成年雄性小鼠中调节E/I平衡和主导行为中的功能.
- 阐明dmPFC天体细胞影响社会等级和等级的机制.
主要方法:
- 在体内纤维光度和双光子显微镜被用来监测星球细胞活动和神经元功能.
- 使用光遗传和化学遗传技术来激活或抑制dmPFC天体细胞.
- 对主导与附属小鼠的突触E/I平衡的分析.
主要成果:
- dmPFC天体细胞操纵双向控制的雄性小鼠主导行为和社会地位.
- 在主导和附属小鼠之间观察到明显的前额突触E / I平衡,由天体细胞活动调节.
- dmPFC星球细胞通过谷氨酸和ATP分别通过谷氨酸和ATP释放来增强突触前刺激性和减少突触后抑制性传播,以控制皮质E / I平衡.
结论:
- dmPFC星体细胞在调节主导行为和在雄性小鼠中建立社会层次方面发挥着关键作用.
- 涉及谷氨酸和ATP信号的星细胞-神经元通信是控制皮质E/I平衡和社会地位的关键机制.
- 这些发现强调了质细胞在复杂的社会行为和神经生物学中的参与.
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