叶酸缺乏可能会增加患有2型糖尿病患者TSH升高的风险
Lin Lin1, Yushan Du2,3, Guanyu Niu4
1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
BMC endocrine disorders
|August 10, 2023
概括
低血清叶酸水平与2型糖尿病 (T2DM) 患者甲状腺刺激激素 (TSH) 升高的风险有关. 这一发现强调了在T2DM管理中对叶酸的监测的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2DM) 和甲状腺功能障碍 (TD) 是常见的内分泌疾病,经常同时发生.
- 叶酸缺乏与T2DM发育有关,但其与TD的关联尚未确立.
- 本研究研究了2型糖尿病患者血清叶酸水平和TD之间的关系.
研究的目的:
- 在被诊断为T2DM的患者中检查血清叶酸度和甲状腺功能障碍之间的关联.
- 为了确定叶酸缺乏与这种人群中甲状腺刺激激素 (TSH) 升高的风险是否相关.
主要方法:
- 分析了北京朝阳医院268名T2DM住院患者 (2020年10月至2021年2月) 的数据.
- 使用化学发光免疫测试 (CLIA) 测量血清叶酸,TSH,FT3和FT4水平.
- 叶酸缺乏症被定义为血清叶酸<4.4 ng/mL;回归模型评估了与TSH的关联.
主要成果:
- 甲状腺功能障碍存在于15.3%的T2DM患者中,其中80.5%的患者呈现高TSH.
- 与正常或低TSH组相比,高TSH组的叶酸缺乏明显更为普遍 (P < 0.001).
- 血清叶酸水平与TSH呈负相关性 (β=-0.062),叶酸缺乏增加了TSH升高的风险 (OR=8.562).
结论:
- 低血清叶酸度与T2DM患者高TSH水平的风险显著增加有关.
- 这些发现表明,在T2DM患者中,叶酸状况和甲状腺功能之间存在潜在的联系.
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