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Updated: Jul 19, 2025

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

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最佳剂量的neostigmine对抗性cisatracurium诱导的浅神经肌肉阻断在老年患者:一个随机对照研究

Mengya Cao1, Huifan Huang2, Jianbin Tong1,3

  • 1Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P.R. China.

BMC anesthesiology
|August 10, 2023
PubMed
概括

尼奥斯蒂格明有效地逆转老年患者的残留神经肌肉阻塞. 40μg/kg的剂量是最佳选择,可以在全身麻醉后更快地恢复神经肌肉功能.

关键词:
老年患者的患者.这种药物是neostigmine.最佳剂量研究最佳剂量研究

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Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
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