无症状的高尿路血症与结石病风险增加有关:一个横截面研究
Haoyuan Deng1,2, Xuehui Zhang1, Nan Cheng3
1School of Public Health, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China.
BMC public health
|August 10, 2023
概括
无症状的高尿素血症增加了结石病的风险. 较高的血清尿酸 (SUA) 水平与较高的结石风险相关,这表明控制SUA是预防的关键.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 石病和痛风具有独立的相关性,高尿血是主要的痛风风险因素.
- 有限的研究已经探索了高尿血症或血清尿酸 (SUA) 作为结石病的独立风险因素.
- 超尿血和结石风险之间的关系需要进一步研究.
研究的目的:
- 为了研究高尿血和结石病风险之间的关联.
- 为了探索血清尿酸 (SUA) 水平和石病风险之间的剂量反应关系.
主要方法:
- 分析了来自中国多民族队列 (CMEC) 研究的22303名30-79岁参与者的队列.
- 使用后勤回归模型来评估高尿血和结石病之间的关联.
- 限制立方脊柱 (RCS) 模型被用来检查SUA和结石风险之间的剂量反应关系.
主要成果:
- 14.5%的参与者患有高尿血,12.1%患有结石病.
- 调整后的分析显示,患有高尿血症的个体患有结石的风险增加了1.464倍 (OR:1.464,95%CI:1.3121.633,p < 0.001).
- 观察到剂量与反应的关系,SUA水平的增加与较高的腎病风险相关,特别是男性超过356μmol/L,女性超过265μmol/L.
结论:
- 无症状的高尿路血症与发展结石病的风险更高有关.
- 随着SUA水平的上升,甲病的风险会升级,甚至在达到诊断性高尿血症标准之前.
- 监测和管理SUA水平可能对有效的甲病预防策略至关重要.
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