预后营养指数 (PNI) 作为术后缺血性中风的潜在预测因素和干预目标:一项回顾性队列研究
Min Liu1,2,3, Miao Sun1,4, Ting Zhang1
1Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.
低的术前预后营养指数 (PNI) 与非心脏手术患者的术后缺血性中风风险增加有关. 这种营养指标可以帮助预测并可能减少中风的发生率.
科学领域:
- 医学研究 医学研究
- 临床营养学 临床营养学
- 外科手术的结果
背景情况:
- 预后营养指数 (PNI) 是众所周知的各种疾病的预测指标.
- 在非心脏手术后预测外科手术期间缺血性中风的作用尚不清楚.
研究的目的:
- 评估手术前PNI与非心脏手术患者缺血性中风风险之间的关联.
- 确定PNI是否可以作为外科手术期间缺血性中风的预测工具.
主要方法:
- 对221,542名接受非心脏手术的患者进行了回顾性队列研究 (2008-2019).
- 根据PNI截止值分类的患者 (≥38.8与<38.8).
- 进行后勤回归和倾向分数匹配 (PSM) 分析,以评估PNI的预测值.
主要成果:
- 0.22%的患者在手术后30天内经历了缺血性中风.
- 较低的PNI (<38.8) 与术后缺血性中风发病率的增加显著相关 (OR=1.306,多变量分析后P=0.011).
- 亚组分析揭示了PNI在特定患者群体的预测效用,包括老年人和接受神经外科手术的人.
结论:
- 在非心脏外科手术中,低的术前PNI是术后缺血性中风的重要独立风险因素.
- 术前PNI评估可以识别高风险患者并指导干预措施以减少中风发生率.
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