早期生活压力的发展神经内分泌学:对儿童发育和行为的影响
Nicolas C Nicolaides1,2,3,4, Christina Kanaka-Gantenbein1, Panagiota Pervanidou5
1Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, 'Aghia Sophia' Children's Hospital, Athens, 11527, Greece.
Current neuropharmacology
|August 11, 2023
概括
应激反应系统保持内部平衡,但长期或过度的压力会导致健康问题. 早期的压力会通过表观遗传变化影响儿童的发育和行为.
科学领域:
- 神经科学和发育生物学.
- 内分泌学和自主神经系统的功能.
- 表观遗传学和分子生物学
背景情况:
- 身体的压力系统,涉及下丘脑-垂体-上腺轴和神经系统的位置coeruleus/norepinephrine-自主神经系统,旨在恢复平衡.
- 压力反应的失调会导致整个生命周期的急性和慢性健康状况.
- 人们越来越认识到,早期的压力是导致非传染性和神经发育障碍的重要因素.
结论:
- 了解压力系统和早期压力的影响对于解决发育和行为障碍至关重要.
- 表观遗传修饰,特别是DNA甲基化,是关键的分子通路,将生命早期的压力与长期健康结果联系起来.
- 对表观遗传学和非编码RNA的作用的进一步研究可以为与压力相关的疾病的干预提供信息.
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