一种新的,简单的标志物用于预测患有正常白细胞计数指标的患者的复杂尾炎;LUC
Erdinc Cetinkaya1, Sukru Melih Bayazitli1, Abidin Göktaş1
1Department of General Surgery, Ankara Bilkent City Hospital, University of Health Sciences, Ankara-Türkiye.
概括
大量的未染色细胞 (LUC) %和总胆红素可以帮助在正常白细胞计数的患者中区分复杂的尾炎. 较低的LUC%和较高的总 bilirubin 是复杂病例的关键指标.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 临床病理学 临床病理学
- 外科胃肠道外科手术
背景情况:
- 区分复杂和不复杂的尾炎对于有效治疗至关重要.
- 在某些尾炎病例中,正常的白细胞 (WBC) 计数可以模糊诊断.
- 当白细胞计数处于正常范围内时,需要易于获得的标记物来帮助诊断.
研究的目的:
- 评估一种新的,易于获得的标记物在区分复杂的和不复杂的尾炎的有用性.
- 为了评估大未染色细胞 (LUC) %的诊断价值,在患有正常白细胞计数的病人中呈现出尾炎.
主要方法:
- 追溯分析了612名经遗传病学证实急性尾炎 (AA) 和正常白血球计数的患者.
- 根据手术和病理发现,将患者分为无并发症 (79.6%) 和并发症 (20.4%) 尾炎组.
- 两组之间实验室参数的比较,包括LUC%,中性粒细胞与淋巴细胞的比率和总 bilirubin.
主要成果:
- 患有并发性尾炎的患者显示显著更高的中性粒细胞%,中性粒细胞与淋巴细胞的比率,C反应蛋白和总 bilirubin 水平.
- 在复杂尾炎组中观察到较低的淋巴细胞%,淋巴细胞数量,淋巴细胞与单细胞的比例,水平和LUC%.
- 较低的LUC% (OR:0.45) 和较高的总 bilirubin (OR:1.50) 被确定为复杂尾炎的独立危险因素.
结论:
- 来自全血细胞计的大型未染色细胞 (LUC) %是预测复杂尾炎的有希望的新参数.
- 这种标志物可以帮助诊断复杂的尾炎,特别是在呈现正常白细胞值的患者中.
- 这些发现表明,LUC%可以在尾炎的临床管理中成为一种有价值,易于使用的工具.
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