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Hui Wang¹, Xuhui Liu^1,2, Xiaofeng Hu¹

¹Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Frontiers in medicine

|August 11, 2023

概括

光学连贯断层扫描血管造影 (OCTA) 显示在糖尿病视网膜病变 (DR) 中,血管密度下降和状血管区域 (FAZ) 面积增加. 这些OCTA参数在区分DR与健康眼睛方面表现出高灵敏度.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
糖尿病并发症糖尿病并发症

背景情况:

糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
了解DR中的微血管变化对于早期检测和管理至关重要.
当前的诊断方法可能无法捕捉早期的结构变化.

研究的目的:

在DR阶段评估 fundus血管密度和微观形态的变化.
评估血液流动和DR严重程度之间的相关性.
在DR检测中确定OCTA参数的诊断值.

主要方法:

对50名患有DR的眼睛,25名没有DR的糖尿病患者和41名健康眼睛进行了观察性横截面研究.
光学连贯性断层扫描血管学 (OCTA) 用于获取状血管区 (FAZ) 区域,表面毛细血管 (SCP) 和深视网膜毛细血管 (DCP) 血管密度.
透密度 (PD) 和骨架血管密度 (SVD) 计算;用于诊断价值评估的接收器操作特征 (ROC) 曲线.

主要成果:

冠状腺和视网膜血管密度 (VD) 在DR组相比健康和没有DR组的DM显著较低.
FAZ区域增加,而副腹VD,PD和SVD随着DR进展而减少.
OCTA参数与DR严重程度有很强的相关性,并且在区分DR与健康眼睛方面表现出高的灵敏度/特异性.

结论:

恶化DR与血管密度降低和FAZ面积增加有关.
OCTA参数 (VD,PD,SVD) 可以作为DR进展的早期生物标志物.
在区分DR与健康眼睛方面,OCTA表现出高的诊断准确度.

关键词:

糖尿病视网膜病变糖尿病视网膜病变光学连贯性断层扫描血管图谱 perfusion 密度 perfusion 密度透密度透密度透密度透密度表面的毛细血管.船舶密度是指船舶的密度.

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