一个深度学习模型用于预测COVID-19 ARDS在重症患者中的预测
Yang Zhou1, Jinhua Feng1, Shuya Mei1
1Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Frontiers in medicine
|August 11, 2023
概括
一个集成的深度学习模型准确地预测了COVID-19危急病患者的急性呼吸窘迫综合征 (ARDS). 该模型结合了临床数据和CT图像,以改善早期检测和患者管理.
科学领域:
- 医疗信息学 医疗信息学
- 人工智能在医学中的应用
- 肺部病理学 肺部病理学
背景情况:
- COVID-19是一种严重的呼吸系统疾病,可能导致ARDS.
- 在COVID-19患者中ARDS的预测模型有限.
- 早期ARDS预测对于及时干预至关重要.
研究的目的:
- 在COVID-19患者中开发和评估ARDS的预测模型.
- 用临床和成像数据比较机器学习模型的性能.
- 为增强ARDS预测建立一个综合模型.
主要方法:
- 对103名重症COVID-19患者的回顾性分析.
- 开发了XGBoost和CNN的预测模型.
- 创建一个综合模型,结合XGBoost和CNN.
- 使用AUC,混矩阵和校准图表进行性能评估.
主要成果:
- 22.3%的患者发生了ARDS.
- 在XGBoost模型中,AUC达到0.94.94.
- 在CNN模型 (基于CT) 中,AUC达到0.96.
- 综合模型实现了最高的AUC 0.97.
结论:
- 一个集成的深度学习模型在预测COVID-19 ARDS方面表现出高准确性.
- 机器学习模型,特别是集成模型,对早期ARDS检测有希望.
- 这种方法可以帮助管理重症COVID-19患者.
相关概念视频
Acute Respiratory Failure-II
272
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
272
Acute Respiratory Failure-III
223
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
223
Acute Respiratory Failure-I
245
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
245
Acute Respiratory Failure-V
163
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
163
Acute Respiratory Failure-IV
176
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
176


