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相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Polymer Classification: Crystallinity01:21

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Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
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相关实验视频

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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
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在流胺酸-三醇复合物中的多态转换.

Yuying Pang1, Simon Gaisford1, Oxana V Magdysyuk2

  • 1UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

International journal of pharmaceutics: X
|August 11, 2023
PubMed
概括
此摘要是机器生成的。

无形固体分散 (ASDs) 提高了药物的溶性,但可能是不稳定的. 这项研究表明,控制流胺酸 (FFA) ASD中的三糖含量会影响结晶路径和药物形式,增强稳定性.

关键词:
不同扫描热量计差异扫描热量计.芬胺酸是一种酸.固体分散是一种固体分散.同步光X射线衍射同步光X射线衍射.这种树脂含有三糖.

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相关实验视频

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学
  • 固态化学 固态化学

背景情况:

  • 无形固体分散 (ASDs) 提高了难以溶解药物的溶解性和生物可用性.
  • 然而,自闭症患者经常表现出不良的物理稳定性,导致再结晶.

研究的目的:

  • 为了研究与三糖配制的ASD中的芬胺酸 (FFA) 的结晶行为.
  • 为了确定配方成分是否可以控制结晶时的FFA的多态形式.

主要方法:

  • 用各种重量比准备FFA-三糖ASD.
  • 使用同时差分扫描热度计 (DSC) 和X射线衍射 (XRD) 监测相位过渡.
  • 在储存和加热/冷却周期时分析药物结晶.

主要成果:

  • 在FFA-三醇ASD中,表现出成分依赖的结晶路径.
  • 低三糖含量 (5:1 FFA:三糖) 在储存时产生表格I FFA,而较高的三糖含量产生表格IV.
  • 所有组合物在加热后再结晶为I型,但随后冷却产生IV型 (低三) 或I型 (高三).

结论:

  • 结晶路径和由此产生的多态形式的芬胺酸从ASDs可以通过调整三糖含量来控制.
  • 谨慎选择配方参数,即使只有一种辅助剂,对于实现稳定的无形固体分散至关重要.